Graphene droplets could be used for drug delivery

Researchers from Monash University have discovered that graphene oxide sheets can change structure to become liquid crystal droplets spontaneously and without any specialist equipment. This opens up possibilities for its use in drug delivery and disease detection, say researchers.

Because graphene droplets change their structure in response to the presence of an external magnetic field, it could be used for controlled drug release applications, said Dr Mainak Majumder from the Faculty of Engineering.

“Drug delivery systems tend to use magnetic particles which are very effective but they can’t always be used because these particles can be toxic in certain physiological conditions,” Dr Majumder said.

“In contrast, graphene doesn’t contain any magnetic properties. This, combined with the fact that we have proved it can be changed into liquid crystal simply and cheaply, strengthens the prospect that it may one day be used for a new kind of drug delivery system.”

Usually atomisers and mechanical equipment are needed to change graphene into a spherical form. In this case all the team did was to put the graphene sheets in a solution to process it for industrial use. Under certain pH conditions they found that graphene behaves like a polymer - changing shape by itself.

The findings, published in the journal ChemComm, build on existing knowledge about graphene. First author of the paper, Rachel Tkacz from the Faculty of Engineering, said the surprise discovery happened during routine tests.

“To be able to spontaneously change the structure of graphene from single sheets to a spherical assembly is hugely significant. No one thought that was possible. We’ve proved it is,” said Tkacz.

“Now we know that graphene-based assemblies can spontaneously change shape under certain conditions, we can apply this knowledge to see if it changes when exposed to toxins, potentially paving the way for new methods of disease detection as well.”

Commonly used by jewellers, the team used an advanced version of a polarised light microscope based at the Marine Biological Laboratory, USA, to detect minute changes to graphene. Dr Majumder said collaborating with researchers internationally and accessing some of the most sophisticated equipment in the world was instrumental to the breakthrough discovery.

“We used microscopes similar to the ones jewellers use to see the clarity of precious gems. The only difference is the ones we used are much more precise due to a sophisticated system of hardware and software. This provides us with crucial information about the organisation of graphene sheets, enabling us to recognise these unique structures,” Dr Majumder said.

Dr Majumder and his team are working with graphite industry partner Strategic Energy Resources and an expert in polarised light imaging, Dr Rudolf Oldenbourg from the Marine Biological Laboratory, USA, to explore how this work can be translated and commercialised. Mark Muzzin, CEO of Strategic Energy Resources Ltd, said the collaboration with Monash was progressing well.

“We are so pleased to be associated with Dr Majumder’s team at Monash university. The progress they have made with our joint project has been astonishing,” he said.